Herbs that Promote Cell Proliferation

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Herbs that Promote Cell Proliferation Hasan NM Al Sorkhy M K ABSTRACT Plants herbs and ethnobotanicals have been in use since the early days of mankind and are still used throughout the world for health promotion and treatment of disease Around 75 of world population especially in the underdeveloped world and developing countries relies on natural pharmaceuticals for primary health care


International Journal of Herbal Medicine, 3 Concerns about herbal therapy induce dermal papilla cells proliferation 34 35 Other herbal. Albeit herbal remedies are wide spread well accepted and extracts can stimulate keratinocyte cell proliferation and avail in. considered safe by many of us there are many concerns that should wound rejuvenating 35 36. be taken into consideration There are few reports discussed. possible carcinogenic ingredients in some well known accepted 5 Immunomodulatory activities. herbal remedies 18 19 A series of kidney failure cases were Ethanol extracts of Allium sativum garlic Glycyrrhiza glabra. reported in 1993 after the ingestion of the weight loss herb licorice Plantago major plantain and Hippophae rhamnoides. Aristolochia fangchi 20 which had been found to possess some sea buckthorn were assessed for their effects on cellular. carcinogenic activity 21 22 A medicinal plant Jussiaea repens L immunity in laying hens Certain extracts definitely enhanced the. that is widely used to treat many ailments in many Asian countries fowl innate and or specific cell immunity and may therefore amend. has been reported to cause adverse effects on male rat reproductive host resistance in poultry Considering the chicken as an important. system 23 non mammalian model that also serves as an available laboratory. approach for some human diseases herbs exerting, 4 Regeneration repair and wound healing immunomodulatory properties may find pertinent clinical. Adult stem cells can be found in virtually all adult tissues It is applications 37. suggested that the utilization of herbal extracts to stimulate. endogenous stem cells to promote rejuvenating and regeneration 6 Radioprotection. could be accommodated as an alternative to stem cell Many herbal extracts have been reported to have a radio protective. transplantation Natural compounds kenned to promote potential The results obtained from an in vitro and in vivo studies. rejuvenating can be investigated on stem cells To advance the indicate that several botanicals such as Gingko biloba Centella. clinical utilization of herbal stem cell therapy in a kindred manner asiatica Hippophae rhamnoides Ocimum sanctum Panax. to stem cell transplantation it is very consequential to find ginseng Podophyllum hexandrum Amaranthus paniculatus. substances that promote endogenous stem cell proliferation and Emblica officinalis Phyllanthus amarus Piper longum Tinospora. differentiation cordifoila Mentha arvensis Mentha piperita Syzygium cumini. It has been found that Aconiti Lateralis Preparata Radix ALR Zingiber officinale Ageratum conyzoides Aegle marmelos and. promoted the proliferation rate of mouse bone marrow Aphanamixis polystachya protect against radiation induced. mesenchymal stem cells m BMMSCs up to 122 24 compared to lethality lipid peroxidation and DNA damage 38 Sah and. untreated cells 24 A dose related effect of blueberry green tea colleagues showed that some herbal extracts exhibitant thermo. catechin carnosine and vitamin D3 was observed on proliferation radiation properties It was found cells exposed to Selaginella. of human bone marrow as compared with human granulocyte extract SE for 1 h afforded complete protection against heat. macrophage colony stimulating factor h GM CSF Furthermore induced growth suppression SE may possess anti stress and. it has been shown that coalescences of nutrients engender a antioxidant activities that could be responsible for the observed. synergistic effect on hematopoietic progenitors by enhancing cell effects Chemical analysis shows that SE contains hexoses and. proliferation This shows that nutrients can act to promote proteins Taken together S bryopteris extract may help in stress. rejuvenating via an interaction with stem cell populations 25 induced complications including those due to heat shock 39. Poon and colleagues studied the effect of herbal extracts on bone. fracture and osteoporosis ethanol extracts of Gendarussa vulgaris 7 Herbal and plant extracts that might cause cancer. and Drynaria quercifolia were investigated on rat bone marrow Some herbs and plants have been found to have deleterious effects. stromal cells and they found that Gendarussa vulgaris could on certain cancer cell lines Croton oil has been long known to. enhance bone cell proliferation 26 Osteoblast like cell induce inflammation and carcinogenesis in different types of cells. proliferation was also been found to be stimulated by herbal Moreover herbal extracts such as Lycium shawii leaves. extracts 27 The C brasiliense I pes caprae and M elaeagnoides extract was found to possess proliferative anti inflammatory and. extracts significantly increased cell proliferation in a dose cytotoxic activity Pure ingredients of these extracts were found to. dependent induction of cell proliferation suggesting T lymphocyte have significant proliferative activity when human embryonic. stimulation 28 Numerous studies showed that herbal extracts can kidney cells were used HEK 293 43 It has also been reported. be used in the management of wound healing A polyherbal that some herbal extracts can stimulate cancer cell proliferation. formulation consisting of extracts of Wrightia tinctoria Aloe vera while others can inhibit it The proliferation of MCF7 cells was. Curcuma longaand Terminalia chebula was used to study the significantly increased following treatment with ecdysterone. fibroblast cell migration and proliferation using scratch wound saffcomin A psoralen or isopsoralen 44 Astragalus plant which. assay technique The results of this study indicate that the has been consumed by humans for over a thousand years and is. polyherbal formulation may be useful in effective management of available in any vitamins shop has a single molecule called TA 65. superficial wounds 29 Herbal extracts were also found to which has been found to activate the telomerase enzyme hence. stimulation growth of skin cells The polysaccharides of St John s stimulating proliferation and fighting aging 45 Therefore. herb were found to stimulate keratinocyte differentiation 30 It has theoretically TA 65 could stimulate unwanted growth and cell. also been reported that hyperforin which is found in significant overpopulation It is also reported that Chinese herbal extracts. amounts in Hypericum perforatum St John s wort induced showed neuro proliferation properties in vitro and in vivo 46 More. keratinocyte differentiation in vitro andskinhydration in vivo 31 32 specifically Rhizome Chuanxiong Radix Scutellaria and Radix. Polysaccharides from Kiwi fruit Actinidia chinensis L were also Phellodendri could promote the proliferation of neural stem cells. found to have a stimulating effect on human keratinocytes 33 A NSCs in a concentration dependent manner Danggui Buxue. mixture of herbal extracts and platelet rich plasma was found to Tang DBT a Chinese herbal decoction used to treat ailments in. International Journal of Herbal Medicine, women contains Radix Astragali Huangqi RA and Radix chemopreventive activity of a mixture of Chinese herbs. Angelicae Sinensis Danggui RAS When DBT was applied onto antitumor B in mouse lung tumor models Oncogene 2004. cultured MG 63 cells osteosarcoma cell line an increase of cell 23 21 3841 3850. proliferation and differentiation was noticed 47 Aristolochic acids 6 Richardson A Straus S Complementary and alternative. AAs are primarily found in different species of the genus medicine opportunities and challenges for cancer. Aristolochia e g Aristolochia clematitis Aristolochia fangchi and management and research Seminars in Oncology 2002. Aristolochia manshuriensis but have also been described in 29 6 531 545. certain Asarum species International Agency for Research on 7 Vickers A Botanical medicines for the treatment of cancer. Cancer 2002 rationale overview of current data and methodological. considerations for Phase I and II trials Cancer Investigation. 8 Angiogenesis immune system 2002 20 7 8 1069 1079. Natural and plant concentrates can likewise impel angiogenesis and 8 Duan YW Huang Y Cai LQ Duan Q Zhu YS Inhibition of. fortify the immune system Peripheral lymphocyte proliferation tumor growth and tumor metastasis by a Chinese herbal. was found to be stimulated after treatment with Chinese medicinal formula ZYD88 in an animal model with metastatic Lewis. herbal extracts CHME Nine CHMEs were experimentally tested lung carcinoma Oncology Reports 2007 17 6 1391 1397. Astragalus polysaccharide APS Isatis root polysaccharide 9 Zhang JT Fan YZ Chen CQ Zhao ZM Sun W. IRPS Epimedium flavone EF Propolis flavone PF Norcantharidin a potential anti angiogenic agent for. Astragalosides AS and Ginsenosides GS were found to promote gallbladder cancers in vitro and in vivo Int J Oncol 2012. lymphocyte proliferation and antibody titer while Epimedium 40 5 1501 14. polysaccharide EPS mainly stimulated cellular immune responses 10 Wei LH Chen YQ Lin JM Zhao JY Chen XZ Xu W et al. The results also suggested that Angelica and ChuanXiong have Scutellaria barbata D Don induces apoptosis of human colon. angiogenic effects and may provide some mechanisms for the carcinoma cell through activation of the mitochondrion. treatment of myocardial infarction and peripheral ischemia 49 On dependent pathway J Med Plant Res 2011 10 1962 1970. the other hand concanavalin a significantly stimulated proliferation 11 Wei LH Lin JM Wu GW Xu W Li H Hong ZF et al. of mice spleen cells from fed with 100 mg rosemary extract Inhibition of tumor angiogenesis by Scutellaria barbata D. compared to control animals 50 51 Anther herbal extract Don via suppressing proliferation migration and tube. Hemidesmus indicus extract was found to significantly stimulate formation of endothelial cells and downregulation of the. lymphocyte cell proliferation at 1 mg ml concentration The extract expression of VEGF A in cancer cells J Med Plant Res 2011. increased the IgG production from cultured PBLs when used at 1 14 3260 3268. mg ml concentration It also increased the ADA activity of PBLs 12 Chia JS Du JL Hsu WB Chiang CP Sun A Lu JJ et al. after 72 h in culture 52 Inhibition of metastasis angiogenesis and tumor growth by. Chinese herbal cocktail Tien Hsien Liquid BMC Cancer. 9 Specific nutrients found in plants and herbs that can 2010 10 175. Promote Stem Cell Proliferation 13 Scheid V Bensky D Ellis A Barolet R Chinese Herbal. When bone marrow stem cell activity is interfered with diseases Medicine Formulas and Strategies Edn 2 Eastland Press. such as anemia red blood cell deficit neutropenia specialized Seattle WA 2009. white blood cell deficit or thrombocytopenia platelet deficit are 14 Bensky D Gamble A St ger E Chinese Herbal Medicine. often diagnosed Scientists have long known that folic acid vitamin Materia Medica Edn 3 Eastland Press Seattle WA 2004. B12 and iron are required for bone marrow stem cells to 15 Peng HR Grand Dictionary of Chinese Medicinal Formula. differentiate into mature red blood cells 53 54 Vitamin D has been Zhong Yi Fang Ji Da Ci Dian 1st edition 1 People s Health. shown to be crucial in the formation of immune cells where bas Press Beijing pp 11131993. carnosine has demonstrated a remarkable ability to rejuvenate cells 16 Sun SM Thousand Ducat Prescriptions Qian Jin Fang Edn. approaching senescence and extend cellular life span 55 56 1 Jilin Publishing Group Co Ltd 2011. 17 Dey SK Banerjee D Chattapadhyay S Karmakar KB, 10 References Antimicrobial activities of some Medicinal Plants of West. 1 Watson JL Hill R Lee PW Giacomantonio CA Hoskin DW Bengal IJPBS 2010 1 3 1 10. Curcumin induces apoptosis in HCT 116 human colon cancer 18 Elvin Lewis M Should we be concerned about herbal. cells in a p21 independent manner Experimental and remedies Journal of Ethno pharmacology 2001 75 2 3 141. 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HP PC SPES inhibits colon cancer growth in vitro and in Medicine 2013 5 197 202. vivo Cancer Research 2002 62 18 5204 5209 22 Poon SL Pang ST McPherson JR Yu W Huang KK Guan P. 5 Zhang Z Wang Y Yao R li J Yan Y et al Cancer et al Genome wide mutational signatures of aristolochic acid. International Journal of Herbal Medicine, and its application as a screening tool Science Translational Radix Astragali and Radix Rehmanniae promote keratinocyte. Medicine 2013 5 197 101 proliferation by regulating expression of growth factor. 23 Ghosal S Chakraborty I Pradhan NK Jussiaea repens L receptors Journal Phytotherapy Research 2012 26 10 1574. Induced Morphological Alterations in Epididymal 1554. 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Egyptian Dermal online Journal 2012 8 1 1 7 breast cancer cells The FASEB Journal 2007 21 973 9. 30 Abakuks S Deters A Polysaccharides of St John s Wort Herb 45 Bernardes JB Schneeberger K Vera E Tajera AM Ayuso E. Stimulate NHDF Proliferation and NEHK Differentiation via Bosch F et al The telomerase activator TA 65 elongates short. Influence on Extracellular Structures Advances in telomeres and increases health span of adult old mice without. Pharmacological Sciences 2012 2012 304317 28 increasing cancer incidence Aging Cell 2011 10 4 604 21. 31 M ller M Essin K Hill K Beschmann H Harteneck C 46 Pao LH Lu SW Sun GG Chiou SH Ma KH Three Chinese. 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